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doi: 10.3389/fmed.2024.1449037 Received 24 June 2024 Accepted 23 September 2024 Published 07 October 2024 Volume 11 - 2024 Edited by Yue Liu, Boston Childrens Hospital, Harvard Medical School, United States Reviewed by Kaige Chen, Wake Forest University, United States Yi-Kai Hong, Northwestern University, United States Updates Copyright 2024 Xie, Cao, Shu, Liu and Zhang

Understanding why all three components appear together, and how they interact, is the foundation of using this compound well

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Some studies have shown evidence of dependence (needing the drug to feel normal and experiencing withdrawal upon cessation) and addiction (craving or wanting the drug) 12 with repeated use, while others have argued that its complex action, though transiently reinforcing, does not lead to neural and behavioral changes typical of addiction